Heikinheimo R, Sievänen H, Jäntti P, Mäki-Jokela P L, Rajala S, Vuori I
Department of Geriatrics, Tampere City Hospital, Finland.
Maturitas. 1996 May;23 Suppl:S77-80. doi: 10.1016/0378-5122(96)01017-1.
The purpose of this study was to investigate whether long-term vitamin D treatment increased bone mineral density in the aged. The bone mineral density in the distal forearm and femoral neck did not differ between nine residents (mean age 81.0 years) of an old peoples' home who had received an annual injection of 150,000 IU ergocalciferol during the foregoing 2-7 years (mean 5.1 years) and nine age-, weight- and height-matched control subjects who had subnormal 25 hydroxyvitamin D level. The alkaline phosphatase and parathyroid hormone levels were clearly higher when the 25 hydroxyvitamin D level was below 10 nmol/1. The authors suggest that the ability of vitamin D treatment to diminish fracture incidence may derive from improved bone quality, not measurable by the standard dual energy X-ray absorptiometry, and/or improved nervous and muscular control of movements to counter the tendency to fall.
本研究的目的是调查长期维生素D治疗是否能提高老年人的骨密度。在一所养老院中，9名居民（平均年龄81.0岁）在前2至7年（平均5.1年）期间每年接受150,000 IU骨化醇注射，其前臂远端和股骨颈的骨密度与9名年龄、体重和身高匹配但25羟维生素D水平低于正常的对照受试者相比并无差异。当25羟维生素D水平低于10 nmol/1时，碱性磷酸酶和甲状旁腺激素水平明显更高。作者认为，维生素D治疗降低骨折发生率的能力可能源于改善了骨质量（这无法通过标准双能X线吸收法测量）和/或改善了神经和肌肉对运动的控制，以对抗跌倒倾向。
