Ghusn H, Arem R, Frazier M, Chamakhi S, Ezzaouia G, Chan L
Department of Medicine Baylor College of Medicine, Houston, TX 77030, USA.
Res Commun Mol Pathol Pharmacol. 1996 Jul;93(1):25-32.
Levels of plasma low density lipoproteins (LDL) are positively, and high density lipoproteins (HDL) are negatively correlated with an increased risk for atherosclerosis. The frequencies of restriction fragment length polymorphism (RFLP) of the genes for apoB, a major LDL apolipoprotein, and apoAII, a major HDL apolipoprotein, were studied in 45 Tunisian diabetics and an equal number of sex and age matched controls. Southern blot analysis of an EcoR1 apoB polymorphism and an Msp1 apo AII polymorphism indicates that there was no statistically significant difference in the incidence of different genotypes or alleles among diabetics compared to controls.
血浆低密度脂蛋白（LDL）水平与动脉粥样硬化风险增加呈正相关，而高密度脂蛋白（HDL）水平则呈负相关。对45名突尼斯糖尿病患者以及同等数量性别和年龄匹配的对照组，研究了主要LDL载脂蛋白apoB和主要HDL载脂蛋白apoAII基因的限制性片段长度多态性（RFLP）频率。对EcoR1 apoB多态性和Msp1 apo AII多态性的Southern印迹分析表明，与对照组相比，糖尿病患者中不同基因型或等位基因的发生率无统计学显著差异。
