Quade R, Löbe L P
Laryngol Rhinol Otol (Stuttg). 1979 Jun;58(6):490-4.
It's possible papillomas of oral, pharyngeal and laryngeal regions concerning clinical and prognostical aspects to divide under a unit principle. In addition to the criterion of juvenile/adult you must consider solitary or multiple appearance, as well as the macroscopical keratinization. An adequate classification under the aspect of the different malignancy on the basis of morphological and clinical examination of 30 papillomas is proposed. The group of adult, multiple and unkeratinized papillomas of the larynx shows in opposite of opinions of today a tendency of malignancy. Infusion therapy with Bleomycin leads to a volume reduction and to a prolongation of the interval on the papillomas of the larynx, who tend to a malignant degeneration and to a short interval.
从临床和预后方面来看，有可能根据统一原则对口腔、咽和喉部的乳头状瘤进行分类。除了青少年/成人标准外，还必须考虑单发或多发情况以及宏观角化情况。在对30例乳头状瘤进行形态学和临床检查的基础上，提出了基于不同恶性程度的适当分类。与当今观点相反，喉部成人、多发且未角化的乳头状瘤组显示出恶性倾向。用博来霉素进行灌注治疗可使喉部乳头状瘤体积缩小，并延长其间隔时间，这些乳头状瘤易于发生恶性变且间隔时间短。
