Tateyama T, Suzuki H, Fukuyama H, Fujiwara R, Abe Y, Okutsu Y
Department of Anesthesiology, Yokohama City, University School of Medicine Urafune Hospital.
Masui. 1996 Feb;45(2):148-52.
We investigated the effects of amrinone on metabolism of regional myocardial tissue during the 40%-decrease of left anterior descending coronary (LAD) flow in anesthetized dogs. Fourteen adult mongrel dogs weighing 15.4 +/- 5.1 kg were anesthetized with 0.5% isoflurane in 50% oxygen and ventilated mechanically to maintain normocapnia. After thoracotomy, regional myocardial tissue PO2 was measured using a monopolar polarographic needle electrode inserted in the myocardium. Electromagnetic blood flow probes were placed around LAD and circumflex artery. A 23-gauge catheter was inserted into a coronary vein which runs along LAD to obtain coronary venous blood for measuring oxygen content, lactate and pyruvate. A variable constrictor was placed distal to the flow-probe. After decreasing LAD flow for 40%, cardiac index (CI) decreased. Systemic venous resistance was decreased and CI was increased by amrinone (50 micrograms.kg-1.min-1) infusion. Myocardial tissue oxygen tension, venous lactate, lactate extraction, lactate-pyruvate ratio and excess lactate were all unchanged by amrinone. In conclusion, amrinone does not impair myocardial aerobic metabolism and increases CI under the stenosis of coronary artery.
我们研究了氨力农对麻醉犬左前降支冠状动脉（LAD）血流减少40%时局部心肌组织代谢的影响。14只体重为15.4±5.1kg的成年杂种犬，用0.5%异氟醚加50%氧气麻醉，并进行机械通气以维持正常碳酸血症。开胸后，使用插入心肌的单极极谱针电极测量局部心肌组织的PO2。电磁血流探头置于LAD和回旋动脉周围。将一根23号导管插入沿LAD走行的冠状静脉以获取冠状静脉血，用于测量氧含量、乳酸和丙酮酸。在血流探头远端放置一个可变收缩器。将LAD血流减少40%后，心脏指数（CI）降低。输注氨力农（50μg·kg-1·min-1）可降低体循环静脉阻力并增加CI。氨力农对心肌组织氧张力、静脉乳酸、乳酸摄取、乳酸-丙酮酸比值及过量乳酸均无影响。总之，氨力农在冠状动脉狭窄情况下不损害心肌有氧代谢并增加CI。
