Alberts V A, Catalano G, Poole M A
Department of Psychiatry, Naval Medical Center, San Diego, Calif, USA.
South Med J. 1996 Oct;89(10):989-91. doi: 10.1097/00007611-199610000-00010.
Prochlorperazine is a centrally acting dopamine receptor antagonist that is most commonly used for the treatment of nausea and vomiting. Like many dopamine antagonists, prochlorperazine has the ability to induce extrapyramidal reactions in susceptible patients. Rarely, however, have cases of tardive dyskinesia been caused by the long-term use of this agent. We report the case of a patient who used prochlorperazine for a prolonged period and, during hospital admission, was found to have a new movement disorder. Alternative antiemetics that do not pose a risk of movement disorders, such as ondansetron and granisetron, are readily available and are efficacious.
丙氯拉嗪是一种中枢性多巴胺受体拮抗剂，最常用于治疗恶心和呕吐。与许多多巴胺拮抗剂一样，丙氯拉嗪有能力在易感患者中诱发锥体外系反应。然而，长期使用该药物导致迟发性运动障碍的病例很少见。我们报告了一例长期使用丙氯拉嗪的患者，在住院期间被发现患有新的运动障碍。有一些不会带来运动障碍风险的替代止吐药，如昂丹司琼和格拉司琼，很容易获得且有效。
