Thongsaard W, Deachapunya C, Pongsakorn S, Boyd E A, Bennett G W, Marsden C A
Department of Physiology, Srinakharinwirot University, Bangkok, Thailand.
Pharmacol Biochem Behav. 1996 Mar;53(3):753-8. doi: 10.1016/0091-3057(95)02088-8.
The behavioural effects of an extract of Cassia siamea, a plant used in Thai traditional medicine, and barakol, its active chemical, were studied on an elevated plus-maze compared with diazepam. An aqueous extract of C. siamea (1, 6, and 12 g/kg body wt., orally) produced a small increase in the percentage of the open: total number of arm entries and time, time spent on the end of the open arms, total number of arm entries, and number of rears/min. Barakol [10 mg/kg, intraperitoneally (IP)] significantly increased all of these behavioural parameters in a manner similar to diazepam (1 mg/kg, IP, 30 or 60 min before testing), except that barakol and not diazepam increased both the number of rears and total arm entries. Barakol at 25 and 50 mg/kg increased the percentage of the open: total number of arm entries and time and number of rears. The results indicate that barakol has anxiolytic properties similar to diazepam but differs from diazepam in that it also increases exploratory and locomotor behaviour, as shown by the number of rears and total arm entries.
在高架十字迷宫实验中，研究了泰国传统医学中使用的植物暹罗决明提取物及其活性化学成分巴拉科尔与地西泮相比的行为效应。暹罗决明水提取物（1、6和12克/千克体重，口服）使开放臂进入总数与总臂进入数的百分比、在开放臂末端停留的时间、总臂进入数以及每分钟站立次数略有增加。巴拉科尔[10毫克/千克，腹腔注射（IP）]以类似于地西泮（1毫克/千克，IP，测试前30或60分钟）的方式显著增加了所有这些行为参数，不同的是，增加站立次数和总臂进入数的是巴拉科尔而非地西泮。25和50毫克/千克的巴拉科尔增加了开放臂进入总数与总臂进入数的百分比、时间以及站立次数。结果表明，巴拉科尔具有与地西泮相似的抗焦虑特性，但与地西泮不同的是，它还会增加探索和运动行为，如站立次数和总臂进入数所示。
