Donati F, Regli F, Regli L, Bogousslavsky J
Service de Neurologie, Centre Hospitalier Universitaire, Lausanne, Switzerland.
Schweiz Arch Neurol Psychiatr (1985). 1995;146(6):264-9.
This non-randomized study surveys the prophylactic treatment of 154 patients after transient ischemic attack or ischemic stroke in the carotid artery territory. Clinical presentation and etiologies were compared on the basis of the proposed prophylactic treatment. A surgical intervention or a long-lasting anticoagulation was restricted to only 30 patients (20%) due especially to the gravity of the ischemic cerebral lesions, general deterioration, and the advanced age of most of the patients. The purpose is to emphasize the "down-to-earth" situation in current medical care of non-selected patients as distinguished from the strictly selected patients of randomized studies. More importance should be done to open studies which better reflect the daily medical reality.
这项非随机研究调查了154例颈动脉区域短暂性脑缺血发作或缺血性卒中患者的预防性治疗。根据所提议的预防性治疗对临床表现和病因进行了比较。特别是由于缺血性脑损伤的严重程度、全身状况恶化以及大多数患者的高龄,只有30例患者(20%)接受了手术干预或长期抗凝治疗。目的是强调当前对未经过严格挑选的患者进行医疗护理时 “实际” 的情况,这与随机研究中经过严格挑选的患者不同。对于能更好反映日常医疗实际情况的开放性研究,应该给予更多重视。