Graff J, Fugleberg S, Brahm J, Fogh-Andersen N
Department of Nephrology, University of Copenhagen, Denmark.
Clin Physiol. 1996 Jan;16(1):31-9. doi: 10.1111/j.1475-097x.1996.tb00554.x.
The mechanisms of transperitoneal sodium transport during hypertonic peritoneal dialysis were evaluated by kinetic modelling. A total of six nested mathematical models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective and lymphatic convective solute transport. Experimental results were obtained from 26 non-diabetic patients undergoing peritoneal dialysis. The model validation procedure demonstrated that only diffusive and non-lymphatic convective transport mechanisms were identifiable in the transperitoneal transport of sodium. Non-lymphatic convective sodium transport was the most important quantitative transport mechanism during the first 90 min of the dwell. Significant sodium sieving was demonstrated and explains the observation of hypernatremia in dialysis with hypertonic dialysis fluid.
通过动力学建模评估了高渗性腹膜透析期间经腹膜钠转运的机制。共设计了六个嵌套的数学模型，以阐明扩散、非淋巴对流和淋巴对流溶质转运的存在与否。实验结果来自26例接受腹膜透析的非糖尿病患者。模型验证程序表明，在经腹膜钠转运中，仅可识别扩散和非淋巴对流转运机制。在驻留的前90分钟内，非淋巴对流钠转运是最重要的定量转运机制。证实了显著的钠筛滤现象，并解释了在使用高渗透析液进行透析时观察到高钠血症的原因。
