Giugliano G, Grieco P, Ialenti A, Mottola M, Perissutti E, Santagada V
Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli.
Boll Soc Ital Biol Sper. 1996 Jan-Feb;72(1-2):29-36.
The synthesis of a series of proline derivatives (1a-e and 2a-b) as pure isomers is described. These compounds were evaluated in vitro for their ability to inhibit angiotensin converting enzyme (ACE) and compared to the potency of captopril taken as a reference drug. They showed only a weak ACE inhibitory activity.
描述了一系列脯氨酸衍生物（1a - e和2a - b）作为纯异构体的合成方法。对这些化合物进行了体外评估，以测定它们抑制血管紧张素转换酶（ACE）的能力，并与作为参考药物的卡托普利的效力进行比较。它们仅表现出微弱的ACE抑制活性。
