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神经肽Y对体外培养的额叶皮质和海马癫痫样活动的抑制作用。

Inhibitory effect of neuropeptide y on epileptiform activity in the frontal cortex and hippocampus in vitro.

作者信息

Bijak M

机构信息

Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.

出版信息

Pol J Pharmacol. 1995 Sep-Oct;47(5):461-3.

PMID:8868141
Abstract

The effect of neuropeptide Y on spontaneous epileptiform discharges was studied in cortical and hippocampal slices using an extracellular recording. Epileptiform activity which was induced by superfusion of slices with Mg(2+)-free medium was attenuated by neuropeptide Y (0.5 microM) in both the frontal cortex and hippocampal CA1 pyramidal cells.

摘要

采用细胞外记录法，在皮质和海马切片中研究了神经肽Y对自发性癫痫样放电的影响。用无镁培养基灌注切片所诱发的癫痫样活动，在额叶皮质和海马CA1锥体细胞中均被神经肽Y（0.5微摩尔）减弱。

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Neuropeptide Y and Epilepsy.
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Knock-out mice reveal a critical antiepileptic role for neuropeptide Y.基因敲除小鼠揭示了神经肽Y的关键抗癫痫作用。
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