Reed R K, Laurent U B, King S, Fraser J R, Laurent T C
Department of Medical and Physiological Chemistry, University of Uppsala, Sweden.
Acta Physiol Scand. 1996 Feb;156(2):93-8. doi: 10.1046/j.1365-201X.1996.471185000.x.
The removal rate of high molecular weight (M(r) 3 x 10(6) [3H]hyaluronan has been measured in rabbit paw skin in control and during increased local venous pressure induced by ligation of the femoral vein. The increased venous pressure resulted in a 20% increase of interstitial volume at 4 h after ligation, a value which relates to at least a doubling of lymph flow, i.e. also to doubling of fluid flux through the tissues. The fractional catabolic rate of hyaluronan was 0.0918 +/- 0.0170 h-1 (n = 10) and 0.0775 +/- 0.0206 h-1 (n = 11) in control and following increased venous pressure respectively (P > 0.05). Since the fractional catabolic rate of hyaluronan is not affected by increased venous pressure, the removal of hyaluronan via lymphatic drainage in rabbit paw skin must be small compared to the local turnover of the polysaccharide.
在对照状态下以及在通过结扎股静脉诱导局部静脉压升高期间，已测量了兔爪皮肤中高分子量（M(r) 3×10(6)）[3H]透明质酸的清除率。静脉压升高导致结扎后4小时间质体积增加20%，该值至少与淋巴流量加倍有关，即也与通过组织的流体通量加倍有关。透明质酸的分解代谢率在对照状态下为0.0918±0.0170 h-1（n = 10），静脉压升高后为0.0775±0.0206 h-1（n = 11）（P>0.05）。由于透明质酸的分解代谢率不受静脉压升高的影响，因此与多糖的局部周转相比，兔爪皮肤中通过淋巴引流清除的透明质酸必定很少。
