Sivam S P
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Gary 46408, USA.
Neuropeptides. 1996 Feb;30(1):103-7. doi: 10.1016/s0143-4179(96)90062-1.
This study examined whether the postnatal development of the biosynthesis of an opioid peptide, dynorphin A (1-8) (DYN) is influenced by dopamine (DA) deficiency. The neurotoxin 6-hydroxydopamine (6-OHDA) was used as a tool to induce DA deficiency on the third day of the postnatal period in Sprague-Dawley rat pups. During the postnatal period, the levels of striatal DYN steadily increased in an age-dependent fashion and appeared to peak between 35 and 45 days. In neonatal 6-OHDA-lesioned animals, the category with 95% or more DA loss exhibited a reduction in the levels of DYN in the postnatal period whereas the category with less than 95% DA loss did not show significant changes in DYN levels. The results indicate that the normal development of striatal DYN is negatively affected only when there is a near-total loss of DA during early postnatal period.
本研究探讨了阿片肽强啡肽A（1-8）（DYN）生物合成的产后发育是否受多巴胺（DA）缺乏的影响。神经毒素6-羟基多巴胺（6-OHDA）被用作一种工具，在出生后第3天诱导斯普拉格-道利大鼠幼崽出现DA缺乏。在出生后期间，纹状体DYN水平以年龄依赖性方式稳步增加，似乎在35至45天之间达到峰值。在新生6-OHDA损伤的动物中，DA损失95%或更多的组在出生后期间DYN水平降低，而DA损失小于95%的组DYN水平未显示出显著变化。结果表明，仅在出生后早期DA几乎完全丧失时，纹状体DYN的正常发育才会受到负面影响。
