β-肾上腺素能受体激动剂诱导的大鼠气管脱敏
beta-Adrenoceptor agonists-induced desensitization in rat trachea.
作者信息
Vassilev P P
机构信息
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
出版信息
Acta Physiol Pharmacol Bulg. 1995;21(3):57-62.
PMID:8868367
Abstract
The development and the characteristics of beta-adrenoceptor agonists-induced desensitization in rat trachea were studied. Tracheal strips were contracted with carbachol and cumulative concentration-response curves for various beta-adrenoceptor agonists were constructed before and after 30-min incubation either with the same beta-adrenoceptor agonist or with another beta-adrenoceptor agonist. Some problems of the in vitro desensitization in rat trachea were also considered.
摘要
研究了大鼠气管中β-肾上腺素能受体激动剂诱导脱敏的发展过程及特征。用卡巴胆碱使气管条收缩，并在与同一β-肾上腺素能受体激动剂或另一种β-肾上腺素能受体激动剂孵育30分钟前后，构建各种β-肾上腺素能受体激动剂的累积浓度-反应曲线。还考虑了大鼠气管体外脱敏的一些问题。
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