Barton J S, Hindmarsh P C, Preece M A
Growth Research Centre, Institute of Child Health, London.
Arch Dis Child. 1996 Aug;75(2):162-3. doi: 10.1136/adc.75.2.162.
Serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and a range of growth and nutritional variables were investigated in 62 infants with congenital heart disease and healthy controls. Infants with congenital heart disease were small, underweight, and had a reduced energy intake. Serum IGF-1 and IGFBP-3 concentrations were significantly reduced. Decreased IGF-1 and IGFBP-3 levels are observed in nutritional deficiency; similar findings in congenital heart disease suggest that undernutrition contributes to the poor growth of these infants. Serial measurements of serum IGF-1 and IGFBP-3 may be helpful in monitoring the effect of nutritional treatment in congenital heart disease.
对62例先天性心脏病患儿及健康对照者的血清胰岛素样生长因子1（IGF-1）、胰岛素样生长因子结合蛋白-3（IGFBP-3）以及一系列生长和营养变量进行了研究。先天性心脏病患儿身材矮小、体重不足且能量摄入减少。血清IGF-1和IGFBP-3浓度显著降低。在营养缺乏时可观察到IGF-1和IGFBP-3水平降低；先天性心脏病中的类似发现表明，营养不足导致了这些患儿的生长发育不良。对血清IGF-1和IGFBP-3进行连续测量可能有助于监测先天性心脏病营养治疗的效果。
