Rajkumar T, Stamp G W, Pandha H S, Waxman J, Gullick W J
ICRF Oncology Unit, Royal Postgraduate Medical School, London, UK.
J Pathol. 1996 Aug;179(4):381-5. doi: 10.1002/(SICI)1096-9896(199608)179:4<381::AID-PATH603>3.0.CO;2-X.
Expression of the c-erbB3 protein was determined in transitional cell carcinoma of the bladder by immunohistochemistry. Strong membrane staining was observed in 10 per cent of cases (7/70) and cytoplasmic and membrane overexpression in 20 per cent (14/70). Overexpression of the epidermal growth factor (EGF) receptor (36 per cent, 25/70) and c-erbB2 proteins (9 per cent 6/70) was determined in the same series of cases. c-erbB3 overexpression was positively correlated with EGF receptor expression (P < 0.025) but appeared to be inversely associated with c-erbB2 overexpression.
通过免疫组织化学法测定膀胱移行细胞癌中c-erbB3蛋白的表达。在10%的病例（7/70）中观察到强膜染色，在20%（14/70）的病例中观察到细胞质和膜的过表达。在同一组病例中测定了表皮生长因子（EGF）受体（36%，25/70）和c-erbB2蛋白（9%，6/70）的过表达。c-erbB3过表达与EGF受体表达呈正相关（P < 0.025），但似乎与c-erbB2过表达呈负相关。
