Blasini A M, Delgado M B, Valdivieso C, Guevara P, Ramirez J L, Stekman I L, Rodriguez M A, Williams R C
Centro Nacional de Enfermedades Reumaticas, Hospital Universitario de Caracas, Venezuela.
Lupus. 1996 Aug;5(4):300-2. doi: 10.1177/096120339600500410.
Previous studies suggest a potential association between human immunoglobulin (Ig) genes and susceptibility to systemic lupus erythematosus (SLE). Ig allotypic determinants seem to confer an increased risk for the disease in various ethnic patient populations. In this study we have examined the pattern of restriction fragment length polymorphisms (RFLP) of constant region lambda (C lambda) light chain genes in a group of 78 Venezuelan patients with SLE and 70 healthy controls. The frequency of the 8-kb allele and the 8/8 genotype was significantly lower in normal Venezuelan controls as compared to healthy British Caucasians (P = 0.0002 and 0.0007 respectively). In turn, Venezuelan controls showed a higher frequency of the 18-kb allele and the 18/18 genotype (P = 0.0002 and 0.0052 respectively). However, there were no statistically significant differences in either parameter between Venezuelan SLE patients and healthy controls. Our study argues against a role for lambda light chain constant region genes in predisposition to SLE.
以往的研究表明，人类免疫球蛋白（Ig）基因与系统性红斑狼疮（SLE）易感性之间可能存在关联。Ig同种异型决定簇似乎会增加不同种族患者群体患该病的风险。在本研究中，我们检测了78名委内瑞拉SLE患者和70名健康对照者中恒定区λ（Cλ）轻链基因的限制性片段长度多态性（RFLP）模式。与健康的英国白种人相比，委内瑞拉正常对照者中8 kb等位基因和8/8基因型的频率显著较低（分别为P = 0.0002和0.0007）。相应地，委内瑞拉对照者中18 kb等位基因和18/18基因型的频率较高（分别为P = 0.0002和0.0052）。然而，委内瑞拉SLE患者与健康对照者在这两个参数上均无统计学显著差异。我们的研究反对λ轻链恒定区基因在SLE易感性中起作用。
