Cervo L, Pozzi L, Samanin R
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Pharmacol Biochem Behav. 1996 Sep;55(1):33-7. doi: 10.1016/0091-3057(96)00046-9.
Three 5-HT3 receptor antagonists, MDL 72222, tropisetron, and ondansetron were studied for their ability to modify the conditioned place preference (CPP) induced by 10 mg/kg IP cocaine in rats. MDL 72222 (0.03-3 mg/kg SC) and tropisetron (0.01-0.1 mg/kg SC) administered, respectively, 30 min and 1 h before each conditioning session, did not affect the acquisition of cocaine CPP. Ondansetron (0.01-0.1 mg/kg SC) administered 30 min before each conditioning session or just before testing likewise had no effect. At 0.1 mg/kg SC ondansetron did not modify the increase of extracellular dopamine caused by 10 mg/kg cocaine in the nucleus accumbens. The results suggest that 5-HT3 receptor antagonists have no effect on the rewarding properties of cocaine or on the behaviour elicited by the stimuli previously associated with the drug's action.
研究了三种5-羟色胺3（5-HT3）受体拮抗剂MDL 72222、托烷司琼和昂丹司琼改变10mg/kg腹腔注射可卡因诱导的大鼠条件性位置偏爱（CPP）的能力。在每次条件训练前30分钟和1小时分别皮下注射MDL 72222（0.03 - 3mg/kg）和托烷司琼（0.01 - 0.1mg/kg），不影响可卡因CPP的获得。在每次条件训练前30分钟或测试前即刻皮下注射昂丹司琼（0.01 - 0.1mg/kg）同样无效。皮下注射0.1mg/kg昂丹司琼不改变10mg/kg可卡因引起的伏隔核细胞外多巴胺增加。结果表明，5-HT3受体拮抗剂对可卡因的奖赏特性或先前与药物作用相关的刺激所引发的行为无影响。
