Harder J A, Kelly M E, Cheng C H, Costall B
School of Pharmacy, University of Bradford, West Yorkshire, UK.
Pharmacol Biochem Behav. 1996 Sep;55(1):61-5. doi: 10.1016/0091-3057(96)00049-4.
A 3-day treatment with p-chlorophenylalanine (pCPA, 100 mg/kg/day) produced a significant decrease (63-89%) in 5-HT levels in both the hippocampus and the cortex of rats, while noradrenaline, adrenaline, and dopamine levels were unaffected. Treatment with pCPA alone did not affect the acquisition of a spatial learning task in the water maze. Treatment with low doses of either scopolamine (0.25 mg/kg) or atropine (10 mg/kg) was also insufficient to cause a significant impairment of water maze acquisition. However, a combined treatment of a 3-day pCPA regimen with the low dose of atropine or scopolamine produced a significant deficit in the acquisition of a water maze task.
用对氯苯丙氨酸（pCPA，100毫克/千克/天）进行为期3天的治疗，使大鼠海马体和皮层中的5-羟色胺水平显著降低（63%-89%），而去甲肾上腺素、肾上腺素和多巴胺水平未受影响。单独使用pCPA治疗不影响水迷宫中空间学习任务的习得。低剂量的东莨菪碱（0.25毫克/千克）或阿托品（10毫克/千克）治疗也不足以导致水迷宫习得显著受损。然而，将3天的pCPA治疗方案与低剂量的阿托品或东莨菪碱联合使用，会使水迷宫任务的习得产生显著缺陷。
