非那西丁与镇痛剂肾病

Phenacetin and analgesic nephropathy.

作者信息

Burry A, Hopkins J

出版信息

Med J Aust. 1977 Jun 11;1(24):879-82. doi: 10.5694/j.1326-5377.1977.tb131210.x.

DOI:10.5694/j.1326-5377.1977.tb131210.x

Abstract

A prospective survey of 322 autopsies of adults conducted some months after phenacetin was removed from a popular compound analgesic showed to reduction in the incidence of advanced or earlier forms of analgesic nephropathy from levels noted in an earlier survey. Apparently active nephropathy was seen in persons taking two different compound analgesics, neither now containing phenacetin. Crystals observed in early and intermediate analgesic nephropathy had no diagnostic significance and represented a tissue breakdown product.

摘要

对322例成人尸体解剖进行的前瞻性调查显示，在一种流行的复方镇痛药中停用非那西丁几个月后，晚期或早期镇痛性肾病的发病率较早期调查中的水平有所降低。在服用两种不同复方镇痛药的人群中发现了明显的活动性肾病，这两种复方镇痛药现在都不含非那西丁。在早期和中期镇痛性肾病中观察到的晶体没有诊断意义，只是一种组织分解产物。