Ong W Y, Leong S K, Garey L J, Reynolds R
Department of Anatomy, National University of Singapore, Singapore.
Exp Brain Res. 1996 Aug;110(3):367-78. doi: 10.1007/BF00229137.
The distribution of the [3H]alpha-amino-3-hydroxy-5-methylisoxzalepropionic acid (AMPA) receptor subunit GluR4 was studied in frontal, parietal and temporal cerebral cortex, subcortical white matter and corpus callosum of neonatal, immature and mature rats. In 1- to 2-day-old rats, a few oligodendrocyte progenitors and amoeboid microglia in the supraventricular part of the corpus callosum were immunolabelled for GluR4. At 7 to 10 days, the number of amoeboid microglia and oligodendrocyte progenitors in white matter increased; many neurons in cortex, including pyramidal neurons, were also moderately labelled for GluR4. The pattern of GluR4 immunostaining in 14-day-old rats was different from that in 7- to 10-day-old rats, but similar to the adult, in that there was no immunoreactivity in microglia and oligodendrocyte progenitors in subcortical white matter. A proportion of non-pyramidal neurons in cortex were moderately labelled, while some pyramidal neurons were lightly labelled. A population of small glial cells with features of oligodendrocyte progenitors were densely labelled in cortex.
研究了新生、未成熟和成熟大鼠额叶、顶叶和颞叶大脑皮质、皮质下白质和胼胝体中[3H]α-氨基-3-羟基-5-甲基异恶唑丙酸（AMPA）受体亚基GluR4的分布情况。在1至2日龄大鼠中，胼胝体室上部分的一些少突胶质前体细胞和阿米巴样小胶质细胞GluR4免疫染色呈阳性。在7至10日龄时，白质中阿米巴样小胶质细胞和少突胶质前体细胞数量增加；皮质中的许多神经元，包括锥体神经元，GluR4免疫染色也呈中度阳性。14日龄大鼠的GluR4免疫染色模式与7至10日龄大鼠不同，但与成年大鼠相似，即皮质下白质中的小胶质细胞和少突胶质前体细胞无免疫反应性。皮质中一部分非锥体神经元免疫染色呈中度阳性，而一些锥体神经元免疫染色呈轻度阳性。皮质中有一群具有少突胶质前体细胞特征的小胶质细胞免疫染色呈强阳性。
