Pardoen D, Bauwens F, Dramaix M, Tracy A, Genevrois C, Staner L, Mendlewicz J
Free University of Brussels, University Clinic of Brussels, Belgium.
Br J Psychiatry. 1996 Aug;169(2):160-6. doi: 10.1192/bjp.169.2.160.
Unipolar and bipolar patients with a chronic illness pattern were investigated to determine whether they experienced a higher number of life events prior to the onset of recurrent affective episodes.
The study participants consisted of 27 recovered bipolar patients, 24 recovered unipolar patients and 26 healthy control subjects. Life events and psychiatric status were assessed by bimonthly interviews over the period of one year using the Inventory for Recent Life Events and the Research Diagnostic Criteria.
In both unipolar and bipolar patients, analyses revealed no significant differences in the number of life events experienced, irrespective of whether the patients had presented with a depressive episode of at least minor intensity during the study (all P > 0.1). Specifically, an increase in marital problems was observed in bipolar patients prior to the onset of recurrent hypomanic and manic episodes (P = 0.06).
The causal association between life events and the onset of depression, shown to be relevant in non-chronically depressed subjects, does not apply in chronic affective disorders. In addition, our results suggest that marital events have an impact on the onset of recurrent hypomanic and manic episodes.
对患有慢性疾病模式的单相和双相情感障碍患者进行调查，以确定他们在复发性情感发作之前是否经历了更多的生活事件。
研究参与者包括27名康复的双相情感障碍患者、24名康复的单相情感障碍患者和26名健康对照者。在一年的时间里，每两个月进行一次访谈，使用近期生活事件量表和研究诊断标准对生活事件和精神状态进行评估。
无论是单相还是双相情感障碍患者，分析显示所经历的生活事件数量没有显著差异，无论患者在研究期间是否出现至少轻度强度的抑郁发作（所有P>0.1）。具体而言，双相情感障碍患者在复发性轻躁狂和躁狂发作之前，婚姻问题有所增加（P=0.06）。
生活事件与抑郁症发作之间的因果关系，在非慢性抑郁症患者中显示出相关性，但不适用于慢性情感障碍。此外，我们的结果表明，婚姻事件对复发性轻躁狂和躁狂发作的发作有影响。
