Appleton M A, Attanoos R L, Jasani B
Department of Pathology, University of Wales College of Medicine, Cardiff, UK.
Histopathology. 1996 Aug;29(2):153-7. doi: 10.1046/j.1365-2559.1996.d01-500.x.
The aim of this study was to evaluate the utility of a new commercially available antibody to thrombomodulin as an endothelial marker in formalin-fixed paraffin-embedded tissue. The expression of thrombomodulin in a variety of 50 vascular and lymphatic neoplasms and malformations was compared to the expression of von Willebrand factor, QBend 10 (CD34) and JC70 (CD31). We showed that thrombomodulin was the best marker of lymphatic endothelium and also stained a higher percentage of malignant vasoformative tumours when compared to the other markers. We recommend the assessment of thrombomodulin expression in the differential diagnosis of malignant vasoformative neoplasms and in the detection of lymphatic endothelium for evidence of tumour permeation.
本研究的目的是评估一种新的市售抗血栓调节蛋白抗体作为福尔马林固定石蜡包埋组织中内皮标志物的效用。将血栓调节蛋白在50种血管和淋巴管肿瘤及畸形中的表达与血管性血友病因子、QBend 10（CD34）和JC70（CD31）的表达进行比较。我们发现，与其他标志物相比，血栓调节蛋白是淋巴管内皮的最佳标志物，并且在恶性血管形成性肿瘤中的染色比例更高。我们建议在恶性血管形成性肿瘤的鉴别诊断以及检测淋巴管内皮以寻找肿瘤浸润证据时评估血栓调节蛋白的表达。
