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[肿瘤免疫学(作者译)]

[Tumour immunology (author's transl)].

作者信息

Sellin D

出版信息

Prax Klin Pneumol. 1979 Apr;33 Suppl 1:341-9.

PMID:88727
Abstract

The anti-tumour immune mechanism as it operates in vivo and in vitro is reviewed. Tumour-specific antigens on the surface of the tumour cell induce cellular (lymphocytes, macrophages) and humoral (antibodies, mediators) reactions which are capable of destroying the tumour cell. The combined operation of these mechanisms is described in detail, e.g. opsonization of tumour cells, enhancement, escape mechanism, specific versus unspecific reactions, potentiation. Analyses of tumour-specific cell-mediated reactions gain more and more importance as attempts to influence the function and differentiation of individual cells become more and more successful.

摘要

本文综述了抗肿瘤免疫机制在体内和体外的作用方式。肿瘤细胞表面的肿瘤特异性抗原可诱导细胞(淋巴细胞、巨噬细胞)和体液(抗体、介质)反应,这些反应能够破坏肿瘤细胞。文中详细描述了这些机制的联合作用,如肿瘤细胞的调理作用、增强作用、逃逸机制、特异性与非特异性反应、增强作用。随着影响单个细胞功能和分化的尝试越来越成功,对肿瘤特异性细胞介导反应的分析变得越来越重要。

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