Chen C, Zhou X F, Rush R A
Department of Human Physiology, Flinders University of South Australia, Adelaide, Australia.
Neurochem Res. 1996 Jul;21(7):809-14. doi: 10.1007/BF02532304.
Previous studies have shown that a subpopulation of large dorsal root ganglion neurons contains neurotrophin-3 (NT3)-like immunoreactivity. It is not known, however, whether these NT3 immunoreactive neurons also express the high affinity receptor for NT3, trkC. In the present study, the distribution and morphology of trkC immunoreactive neurons have been correlated with those of NT3 immunoreactive neurons in the dorsal root ganglia. Size and segmental distributions of both antigens indicate that they are present in the same group of large sensory neurons. Almost twice the number of these neurons are present in the cervical and lumbar spinal ganglia than in the thoracic. Co-localization study indicates that 94% of NT3 immunoreactive neurons express trkC. Our findings support the proposal that NT3 in these neurons is derived from their peripheral targets rather than synthesized in situ.
先前的研究表明，大的背根神经节神经元亚群含有神经营养素-3（NT3）样免疫反应性。然而，尚不清楚这些NT3免疫反应性神经元是否也表达NT3的高亲和力受体trkC。在本研究中，背根神经节中trkC免疫反应性神经元的分布和形态已与NT3免疫反应性神经元的分布和形态相关联。两种抗原的大小和节段分布表明它们存在于同一组大的感觉神经元中。这些神经元在颈和腰脊髓神经节中的数量几乎是胸段的两倍。共定位研究表明，94%的NT3免疫反应性神经元表达trkC。我们的研究结果支持这样的观点，即这些神经元中的NT3来源于其外周靶标，而非原位合成。
