Lantz M S, Marin D
Jewish Home and Hospital for Aged, Mount Sinai School of Medicine, New York, New York 10025, USA.
J Geriatr Psychiatry Neurol. 1996 Jul;9(3):107-19. doi: 10.1177/089198879600900301.
Agitated behaviors are a common and nearly universal occurrence among patients suffering from dementing illnesses. The pharmacologic treatments available for this troubling syndrome are varied, but treatment studies are limited. Clinicians are frequently faced with the challenging management of patients with disruptive behavior who fail to respond to trials with multiple agents. This review summarizes available treatment studies of agitation in dementia and offers a guide to therapy and management. Reports of therapies for agitation in dementia are limited by lack of controlled studies, variability of diagnostic criteria and outcome measures, and small sample size. The need for carefully designed, well-controlled studies of outcome in this growing population is formidable. It is imperative to identify effective and well-tolerated treatment strategies to reduce the morbidity of these distressing and burdensome symptoms.
激越行为在患有痴呆症的患者中很常见，几乎普遍存在。针对这种令人困扰的综合征的药物治疗多种多样，但治疗研究有限。临床医生经常面临对行为紊乱且对多种药物试验无反应的患者进行具有挑战性的管理。本综述总结了痴呆症激越的现有治疗研究，并提供了治疗和管理指南。痴呆症激越治疗的报告受到缺乏对照研究、诊断标准和结局测量的变异性以及样本量小的限制。对于这一不断增长的人群，开展精心设计、严格对照的结局研究的需求非常迫切。必须确定有效且耐受性良好的治疗策略，以降低这些令人痛苦和负担沉重的症状的发病率。
