Amadeo M
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555-0428, USA.
J Geriatr Psychiatry Neurol. 1996 Jul;9(3):142-5. doi: 10.1177/089198879600900307.
Three demented patients who manifested an aggressive syndrome and motor disturbances including agitation, pacing, and restlessness received a therapeutic trial of the antiandrogen agents medroxyprogesterone acetate and luprolide acetate. Within 4 weeks of the start of the antiandrogen therapy, verbal and physical aggressivity had ceased; activity disturbances such as agitation, pacing, and restlessness were markedly reduced. One patient also manifested marked disinhibited and disruptive sexual behavior. Following treatment, that behavior also ceased. Further control studies assessing the efficacy and safety of antiandrogen agents are recommended.
三名患有痴呆症且表现出攻击综合征和运动障碍（包括激动、踱步和坐立不安）的患者接受了抗雄激素药物醋酸甲羟孕酮和醋酸亮丙瑞林的治疗试验。在抗雄激素治疗开始后的4周内，言语和身体攻击行为停止；激动、踱步和坐立不安等活动障碍明显减轻。一名患者还表现出明显的性抑制解除和破坏性行为。治疗后，该行为也停止了。建议进行进一步的对照研究以评估抗雄激素药物的疗效和安全性。
