Gustafsson U, Sollevi A, Sirsjö A, Sjöberg F
Clinical Research Center, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Acta Anaesthesiol Scand. 1996 Aug;40(7):832-7. doi: 10.1111/j.1399-6576.1996.tb04541.x.
Adenosine (ADO)-induced hypotension during diethyl ether anesthesia has been shown to increase skeletal muscle oxygenation. Whether this beneficial effect of ADO hypotension is present also during another anesthetic technique was tested in the present study using ketamine-xylazine anesthesia, and its actions were compared with sodium nitroprusside (SNP) and acetylcholine (ACh) induced hypotension in rabbits.
Local oxygen pressure and capillary blood flow were measured with a multiwire microelectrode which was placed on the surface of the left vastus medialis muscle. The experiments were performed in three groups, in which either ADO, SNP or ACh was infused into a central vein in a dose that produced a reduction of the mean arterial pressure by 20-25%, to approximately 60 mmHg.
In the ADO group (60-170 micrograms kg-1 min-1) the tissue oxygen pressures increased by 23% while capillary blood flow decreased by 38%. During SNP administration (1-3 micrograms kg-1 min-1) the oxygen pressures decreased by 21% and an increase of 31% in capillary flows was seen. When ACh was infused (1-4 micrograms kg-1 min-1) the oxygen pressures decreased by 21% and, in parallel, capillary blood flow decreased by 50%. During hypotension no low tissue oxygen pressure values (< 1.5 kPa) were found in the ADO group, whereas they were present in both the SNP and ACh group.
Compared to sodium nitroprusside and acetylcholine, adenosine appears to have an oxygen-sparing effect in the skeletal muscle during pharmacologically induced hypotension.
已表明在乙醚麻醉期间腺苷（ADO）诱导的低血压可增加骨骼肌氧合。本研究使用氯胺酮-赛拉嗪麻醉测试了在另一种麻醉技术期间是否也存在 ADO 低血压的这种有益作用，并将其作用与硝普钠（SNP）和乙酰胆碱（ACh）诱导的家兔低血压进行了比较。
用置于左股内侧肌表面的多丝微电极测量局部氧分压和毛细血管血流。实验分三组进行，分别向中心静脉输注 ADO、SNP 或 ACh，剂量使平均动脉压降低 20% - 25%，降至约 60 mmHg。
在 ADO 组（60 - 170 微克·千克⁻¹·分钟⁻¹），组织氧分压升高 23%，而毛细血管血流减少 38%。在给予 SNP（1 - 3 微克·千克⁻¹·分钟⁻¹）期间，氧分压降低 21%，毛细血管血流增加 31%。当输注 ACh（1 - 4 微克·千克⁻¹·分钟⁻¹）时，氧分压降低 21%，同时毛细血管血流减少 50%。在低血压期间，ADO 组未发现低组织氧分压值（< 1.5 kPa），而 SNP 组和 ACh 组均出现。
与硝普钠和乙酰胆碱相比，在药理学诱导的低血压期间，腺苷在骨骼肌中似乎具有氧保护作用。
