Weiss D J, Geor R J, Burger K
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108, USA.
Am J Vet Res. 1996 Sep;57(9):1364-8.
To determine whether pentoxifylline treatment altered hematologic, rheologic, electrolyte, or blood gas test results of Thoroughbreds during submaximal treadmill exercise.
5 healthy Thoroughbreds that had raced within the past year and had no history of exercise-induced pulmonary hemorrhage.
Mixed venous blood samples were obtained before exercise, at treadmill speeds of 9 and 13 m/s, and 20 minutes after exercise; hematologic, rheologic, electrolyte, and blood gas test results were determined.
Pentoxifylline treatment resulted in a 45% reduction in RBC filtration pressures for horses at rest. The improved RBC filterability persisted during treadmill exercise. Horses treated with pentoxifylline had a greater decrease in Po2 values and a lesser increase in plasma lactate concentration during treadmill exercise.
Administration of pentoxifylline improved RBC deformability of horses at rest and during treadmill exercise.
Improved RBC deformability resulting from pentoxifylline treatment may reduce exercise-associated shear stress in pulmonary capillaries, thereby attenuating exercise-induced pulmonary hemorrhage.
确定己酮可可碱治疗是否会改变纯种马在次最大强度跑步机运动期间的血液学、流变学、电解质或血气测试结果。
5匹健康的纯种马，这些马在过去一年内参加过比赛且无运动性肺出血病史。
在运动前、跑步机速度为9米/秒和13米/秒时以及运动后20分钟采集混合静脉血样本；测定血液学、流变学、电解质和血气测试结果。
己酮可可碱治疗使静息状态下马的红细胞滤过压降低了45%。在跑步机运动期间，红细胞可滤过性的改善持续存在。在跑步机运动期间，接受己酮可可碱治疗的马的氧分压值下降幅度更大，血浆乳酸浓度升高幅度更小。
己酮可可碱给药改善了马在静息状态和跑步机运动期间的红细胞变形性。
己酮可可碱治疗导致的红细胞变形性改善可能会降低肺毛细血管中与运动相关的剪切应力，从而减轻运动性肺出血。
