Donadio C, Tramonti G, Lucchesi A, Giordani R, Lucchetti A, Bianchi C
Unità di Nefrologia Clinica Medica 2, University of Pisa, Italy.
Ren Fail. 1996 Jul;18(4):647-56. doi: 10.3109/08860229609047690.
The aim of this study is to evaluate the effects of contrast media on both tubular and glomerular function. Different parameters of tubular and glomerular function were determined before and at 1, 3, and 5 days after the intravascular administration of contrast media in 100 adult renal patients (plasma creatinine 0.6-10.8 mg/dL, mean: 1.3). Urinary activities of five tubular enzymes (alanine aminopeptidase, gamma-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase, N-acetyl-beta-D-glucosaminidase) increased significantly on the first day after the administration of contrast media, indicating a tubular damage. Glomerular filtration rate and the conventional tests of glomerular function (plasma creatinine, creatinine clearance, and urinary proteins) presented only slight variations after the administration of contrast media. In conclusion, contrast media principally affected the renal tubule (as demonstrated by enzymuria), while their effects on glomerular function were very mild.
本研究的目的是评估造影剂对肾小管和肾小球功能的影响。在100例成年肾病患者（血浆肌酐0.6 - 10.8mg/dL，平均：1.3）血管内注射造影剂之前以及注射后1天、3天和5天，测定肾小管和肾小球功能的不同参数。注射造影剂后第一天，五种肾小管酶（丙氨酸氨基肽酶、γ-谷氨酰转移酶、碱性磷酸酶、乳酸脱氢酶、N-乙酰-β-D-氨基葡萄糖苷酶）的尿活性显著增加，表明存在肾小管损伤。注射造影剂后，肾小球滤过率和肾小球功能的常规检测指标（血浆肌酐、肌酐清除率和尿蛋白）仅有轻微变化。总之，造影剂主要影响肾小管（如酶尿所示），而其对肾小球功能的影响非常轻微。
