Ehara Y, Yamaguchi M
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Japan.
Res Exp Med (Berl). 1996;196(3):163-70. doi: 10.1007/BF02576838.
The alteration of mineral content in the femoral metaphysis of rats with skeletal unloading was investigated using a model of hindlimb suspension. Animals were fed for 4 days during the unloading. The femoral length, femoral dry weight and femoral mineral density were significantly decreased by the unloading. The calcium, phosphorus and zinc contents in the femoral metaphysis were appreciably reduced by the unloading, although, except for zinc, similar decreases were not seen in the femoral diaphysis. Moreover, the trabecular bone at the femoral metaphysis was clearly reduced by the unloading. Skeletal unloading caused a decrease in osteoid tissue in the primary and secondary spongiosa, indicating that osteoblastic bone formation may be inhibited. The present results clearly demonstrate that skeletal unloading can induce bone loss in the femoral metaphysis.
利用后肢悬吊模型研究了骨骼卸载大鼠股骨近端干骺端矿物质含量的变化。在卸载期间动物饲养4天。卸载导致股骨长度、股骨干重和股骨矿物质密度显著降低。卸载使股骨近端干骺端的钙、磷和锌含量明显减少，不过，除锌外，股骨干中未见类似程度的降低。此外，卸载明显减少了股骨近端干骺端的小梁骨。骨骼卸载导致初级和次级骨小梁中类骨质组织减少，表明成骨细胞的骨形成可能受到抑制。目前的结果清楚地表明，骨骼卸载可导致股骨近端干骺端骨质流失。
