Bilgihan K, Bilgihan A, Akata F, Hasanreisoğlu B, Türközkan N
Department of Ophthalmology, Gazi University Medical Faculty, Ankara, Turkey.
Jpn J Ophthalmol. 1996;40(2):154-7.
Corneal photoablation with 193 nm argon fluoride excimer laser is a new technique for the treatment of refractive errors and for removing corneal opacities and irregularities. Ultraviolet radiation and thermal injury induce free radical formation in the tissues. The aim of this study was to confirm the production of free radicals by excimer laser photoablation in rabbits. The thermal changes of the posterior corneal surface were recorded during excimer laser photoablation. The lipid peroxide (LPO) levels and superoxide dismutase (SOD) activities of aqueous humour were measured after excimer laser keratectomy. The aqueous LPO levels were not changed after excimer laser ablation, but both the thermal increase in the cornea during the photoablation and the decreased aqueous SOD activities suggest that free radicals are formed in the cornea during excimer laser keratectomy, and that they may be responsible for some of the complications of excimer laser corneal surgery.
用193纳米氟化氩准分子激光进行角膜光消融是一种治疗屈光不正以及去除角膜混浊和不规则的新技术。紫外线辐射和热损伤会诱导组织中自由基的形成。本研究的目的是证实准分子激光光消融在兔体内产生自由基的情况。在准分子激光光消融过程中记录角膜后表面的热变化。准分子激光角膜切削术后测量房水中脂质过氧化物（LPO）水平和超氧化物歧化酶（SOD）活性。准分子激光消融后房水LPO水平未改变，但光消融过程中角膜的热升高以及房水SOD活性降低表明，在准分子激光角膜切削术中角膜中会形成自由基，并且它们可能是准分子激光角膜手术某些并发症的原因。
