Geme J W
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, St. Louis, MO 63110, USA.
Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 2):S192-6. doi: 10.1164/ajrccm/154.4_Pt_2.S192.
Haemophilus influenzae is a human-specific pathogen that must colonize the human upper respiratory tract to avoid extinction. On occasion, organisms penetrate the epithelial barrier and cause bacteremic disease or spread within the respiratory tract to produce localized disease. Attachment to host epithelium is fundamental to the process of colonization and to the pathogenesis of disease. Accordingly, H. influenzae has evolved to express a number of factors that promote interaction with human epithelial cells. Our current understanding of H. influenzae type b and nontypable H. influenzae adhesins is reviewed in this report. In addition, models are proposed for the interrelationship of these molecules.
流感嗜血杆菌是一种特定寄生于人类的病原体，它必须定殖于人类上呼吸道以避免灭绝。偶尔，该微生物会穿透上皮屏障，导致菌血症性疾病，或在呼吸道内扩散以引发局部疾病。附着于宿主上皮细胞是定殖过程和疾病发病机制的基础。因此，流感嗜血杆菌已经进化出多种促进与人类上皮细胞相互作用的因子。本报告综述了我们目前对b型流感嗜血杆菌和不可分型流感嗜血杆菌黏附素的认识。此外，还提出了这些分子相互关系的模型。
