Tocino I, Garcia B M, Carter D
Department of Radiology, Yale University School of Medicine, New Haven, CT 06520-8042, USA.
Ann Surg Oncol. 1996 Sep;3(5):483-8. doi: 10.1007/BF02305767.
To correlate the stereotaxic core needle biopsy results with those of surgical biopsy in patients with atypical lobular or ductal hyperplasia (atypical hyperplasia) diagnosed at stereotaxic core needle biopsy (SCNB).
We retrospectively reviewed the mammograms and pathology reports of 358 consecutive SCNBs performed in 323 patients. The results of SCNBs of 22 lesions reported as atypical hyperplasia were correlated with histologic findings at surgical biopsy.
A histologic diagnosis of atypical hyperplasia at SCNB was found to be a poor predictor of the final surgical results. In the 19 patients with 22 lesions, surgical biopsy and SCNB results were in disagreement in 16, partial agreement in two, and complete agreement in only four lesions. Furthermore, five cases of atypical hyperplasia were shown to have invasive carcinoma on open biopsy, and five had ductal carcinoma in situ in the surgical biopsy, none of which was present on SCNB.
Given the frequent occurrence of malignancy in patients diagnosed with atypical hyperplasia by SCNB, it is recommended that all such patients undergo excisional biopsy.
将立体定向芯针活检结果与经立体定向芯针活检（SCNB）诊断为非典型小叶或导管增生（非典型增生）患者的手术活检结果进行对比。
我们回顾性分析了323例患者连续进行的358次SCNB的乳房X线照片和病理报告。将报告为非典型增生的22个病变的SCNB结果与手术活检的组织学结果进行对比。
发现SCNB时非典型增生的组织学诊断对最终手术结果的预测性较差。在19例有22个病变的患者中，手术活检和SCNB结果不一致的有16例，部分一致的有2例，完全一致的仅4个病变。此外，5例非典型增生病例在开放活检时显示为浸润性癌，5例在手术活检时有导管原位癌，而SCNB时均未发现。
鉴于经SCNB诊断为非典型增生的患者中恶性肿瘤发生率较高，建议所有此类患者接受切除活检。
