Histopathologic alterations of periodontium in cyclosporin-treated rats. Is the periodontium a target tissue for the drug?

Gingival dimensions and histopathologic alterations in periodontium were examined in rats continuously exposed to cyclosporin-A (CSA). 60 male Sprague-Dawley rats were divided into 2 groups. Rats in the test group daily received CSA in mineral oil by gastric feeding at a dosage of 30 mg/kg body weight for 6 weeks. Rats in the control group received mineral oil only. 10 rats from each group were sacrificed at 2-week intervals. Gingival dimensions were assessed from stone models obtained from the maxillary and mandibular incisal regions. Horizontal, sagittal and frontal tissue sections were obtained from these regions as well. Gingival dimensions in the mandibular and maxillary incisal regions were significantly increased in rats exposed to CSA. Light-microscopic observations revealed a granulation tissue formation at tooth-gingiva interface and an irregular bony surface on dental alveoli in experimental animals. Because both soft and hard tissue of periodontium in experimental rats being significantly effected by CSA compared to control animals, we hypothesized that the periodontium is a target tissue for CSA.