Aikawa T, Kojima M, Onishi H, Tamura R, Fukuda S, Suzuki T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
Aikawa Internal Hospital, Japan.
J Med Virol. 1996 Aug;49(4):274-8. doi: 10.1002/(SICI)1096-9071(199608)49:4<274::AID-JMV3>3.0.CO;2-0.
Some HLA class II alleles and haplotypes were examined by restriction fragment length polymorphism of corresponding DNA fragments amplified by the polymerase chain reaction in 117 patients with chronic hepatitis C in Japan. The prevalence rates were compared between patients and 1216 controls and in 67 patients with liver cirrhosis, of whom 20 had hepatocellular carcinoma and 50 patients with chronic hepatitis who did not have cirrhosis or hepatocellular carcinoma. Notably, DRB10405 (49% [95% confidence range 38-60%] vs. 26% [16-40%]; P < 0.05, relative risk [rr] = 2.8) and DQB10401 (43% [33-54%] vs. 22% [13-34%]; P < 0.05, rr = 2.1) were detected more frequently in patients with cirrhosis than in those without cirrhosis. By contrast, DRB10901 (11% [6-19%] vs. 28% [18-40%]; P < 0.05; rr = 0.3) and DQB10303 (11% [6-19%] vs. 36% [25-49%]; P < 0.01; rr = 0.2) were detected less frequently in patients with cirrhosis than those without cirrhosis. Accordingly, the DRB10405-DQB10401 haplotype was more common (43% [33-54%] vs. 22% [13-34%]; P < 0.05; rr = 2.7), while the DRB10901-DQB10303 haplotype was less common (9% [4-17%] vs. 28% [18-40%]; P < 0.05; rr = 0.3) in patients with cirrhosis than in those without cirrhosis. These results suggest that there would be HLA class II alleles and haplotypes which may be associated with an accelerated or slower progression of chronic hepatitis C towards cirrhosis and eventually to hepatocellular carcinoma.
在日本，对117例慢性丙型肝炎患者，通过聚合酶链反应扩增相应DNA片段的限制性片段长度多态性，检测了一些HLA - II类等位基因和单倍型。比较了患者与1216名对照以及67例肝硬化患者（其中20例有肝细胞癌）和50例无肝硬化或肝细胞癌的慢性肝炎患者之间的患病率。值得注意的是，DRB10405（49%[95%置信区间38 - 60%]对26%[16 - 40%]；P < 0.05，相对风险[rr]=2.8）和DQB10401（43%[33 - 54%]对22%[13 - 34%]；P < 0.05，rr = 2.1）在肝硬化患者中的检出频率高于无肝硬化患者。相比之下，DRB10901（11%[6 - 19%]对28%[18 - 40%]；P < 0.05；rr = 0.3）和DQB10303（11%[6 - 19%]对36%[25 - 49%]；P < 0.01；rr = 0.2）在肝硬化患者中的检出频率低于无肝硬化患者。因此，DRB10405 - DQB10401单倍型更常见（43%[33 - 54%]对22%[13 - 34%]；P < 0.05；rr = 2.7），而DRB10901 - DQB10303单倍型在肝硬化患者中比无肝硬化患者更少见（9%[4 - 17%]对28%[18 - 40%]；P < 0.05；rr = 0.3）。这些结果表明，可能存在一些HLA - II类等位基因和单倍型，它们可能与慢性丙型肝炎向肝硬化并最终发展为肝细胞癌的加速或缓慢进展有关。
