[Effect of axoplasmic flow elimination and denervation on the contents of protein, nucleic acids and glycogen in rat muscle].

Disturbance of the axoplasmic flow was evoked by ligation of the sciatic nerve with a silk thread moistened with 0.05 solution of colchicine (exposition for 30 s). No intoxication was observed in the animals, the motor function of the operated extremety was preserved. Two weeks after elimination of the axoplasmic flow practically the same changes in the content of contractile and sarcoplasmic proteins, glycogen, DNA and RNA were observed in musculi gastrocnemius as with surgical denervation. The data obtained evidence for an important role of the axoplasmic flow to maintain the normal metabolism in muscles.