Hong C B
Livestock Disease Diagnostic Center, University of Kentucky, Lexington 40511, USA.
J Comp Pathol. 1996 Jul;115(1):85-8. doi: 10.1016/s0021-9975(96)80030-2.
Three cases of congenital polyalveolar lobe (pulmonary hamartoma) were diagnosed in female Thoroughbred foals. Foal 1 was born at full term but died shortly afterwards. Foal 2 was aborted at the seventh month of gestation. Parturition was induced at the tenth month of gestation in foal 3 because it developed hydrops of the amnion and ascites. In all three foals, the polyalveolar lobe occurred on the right side and affected the entire right lung. In each case, the right lung formed a tumour-like mass, and expanded into the left chest cavity. The lung masses were pink to dark red and spongy to rubbery, with marked lobular patterns on the pleural and cut surfaces. The left lung was compressed and small. The right and left lungs weighed 0.9-6.3 kg and 80 g-0.3 kg, respectively. Microscopically, the polyalveolar lobe consisted of normal alveoli, bronchioli and blood vessels, but the alveolus:artery ratio was greater than normal. In the polyalveolar lobe of two foals the numbers of alveoli per artery were 65.2 and 52.5; in contrast, the corresponding values for three control lungs were 26.9, 26.5 and 27.6. Chronic passive congestion with generalized oedema was observed in foals 2 and 3.
在纯种雌性马驹中诊断出三例先天性多肺泡叶（肺错构瘤）。马驹1足月出生，但出生后不久死亡。马驹2在妊娠第七个月时流产。马驹3在妊娠第十个月时因出现羊膜积水和腹水而引产。在所有三匹马驹中，多肺泡叶均发生在右侧，并累及整个右肺。在每例中，右肺形成一个肿瘤样肿块，并扩展至左胸腔。肺肿块呈粉红色至暗红色，质地从海绵状到橡胶状，在胸膜和切面上有明显的小叶形态。左肺受压且体积小。右肺和左肺的重量分别为0.9 - 6.3千克和80克 - 0.3千克。显微镜下，多肺泡叶由正常的肺泡、细支气管和血管组成，但肺泡与动脉的比例高于正常。在两匹马驹的多肺泡叶中，每条动脉的肺泡数量分别为65.2和52.5；相比之下，三个对照肺的相应值为26.9、26.5和27.6。在马驹2和3中观察到慢性被动性充血伴全身性水肿。
