Ronald K, Tessaro S V, Uthe J F, Freeman H C, Frank R
Sci Total Environ. 1977 Jul;8(1):1-11. doi: 10.1016/0048-9697(77)90057-2.
Hematological and blood chemistry values were examined in harp seals (Pagophilus groenlandicus) exposed to daily oral dosages of methylmercuric chloride (MMC). Two seals, exposed to 0.25 mg MMC/kg body weight/day for 60 and 90 days, respectively, did not show abnormal blood values. Two other seals exposed to 25.0 mg MMC/kg body weight/day died on day 20 and 26 of exposure. Blood parameters indicated toxic hepatitis, uremia and renal failure. Total mercury and methylmercury values in the tissues of the experimental animals indicated that harp seals can tolerate high levels of mercury in the brain and that the observed renal and hepatic dysfunction were related to the high accumulation of mercury in these tissues. Tests of renal function are useful in cases of severe methylmercury poisoning.
对每日口服甲基氯化汞（MMC）的格陵兰海豹（Pagophilus groenlandicus）进行了血液学和血液化学值检测。两只分别暴露于0.25毫克MMC/千克体重/天，持续60天和90天的海豹，未显示出血液值异常。另外两只暴露于25.0毫克MMC/千克体重/天的海豹在暴露的第20天和第26天死亡。血液参数表明存在中毒性肝炎、尿毒症和肾衰竭。实验动物组织中的总汞和甲基汞值表明，格陵兰海豹能够耐受大脑中高水平的汞，并且观察到的肾脏和肝脏功能障碍与这些组织中汞的高积累有关。肾功能测试在严重甲基汞中毒的病例中很有用。
