Lindgren V
Department of Obstetrics and Gynecology, University of Chicago, Illinois, USA.
Endocrinol Metab Clin North Am. 1996 Sep;25(3):503-21. doi: 10.1016/s0889-8529(05)70338-8.
This review has briefly considered some of the vast amount of information that has been gathered on genomic imprinting and its role in PWS, AS, BWS and Russell-Silver syndrome. The pace of investigation into the phenomenon of imprinting will undoubtedly continue, because our understanding remains far from complete. Newer approaches to identifying imprinted genes based on their expression rather than their location are likely to uncover currently unknown genes. We can also look forward to more insight into the fascinating complexities of the imprinting process.
本综述简要探讨了关于基因组印记及其在普拉德-威利综合征、天使综合征、贝威二氏综合征和罗素-西尔弗综合征中作用的大量已收集信息中的一些内容。对印记现象的研究步伐无疑将继续,因为我们的理解仍远未完整。基于基因表达而非其位置来鉴定印记基因的新方法可能会发现目前未知的基因。我们也期待对印记过程引人入胜的复杂性有更多的深入了解。