Henley C M, Weatherly R A, Martin G K, Lonsbury-Martin B
Department of Otorhinolaryngology/Communicative Sciences, Baylor College of Medicine, Houston, TX 77083, USA.
Hear Res. 1996 Sep 1;98(1-2):93-103. doi: 10.1016/0378-5955(96)00077-9.
The developing rat is hypersensitive to aminoglycoside toxicity, which is expressed early on as a destruction of outer hair cells (OHC). In the current study, distortion-product otoacoustic emissions (DPOAE), which specifically measure the micromechanical activity of OHCs, were used to assess functional effects of administering a regimen of kanamycin to three groups of neonatal rats representing discrete postnatal developmental periods. In this manner, pigmented rats were treated at postnatal days 1-10, 11-20, and 21-30. A series of input-output (I/O) functions obtained for the 2f1-f2 DPOAE during the post-treatment period indicated that detection thresholds were significantly elevated for the animals treated on postnatal days 1-10 and 11-20, with the greatest elevations observed at the higher test frequencies.
发育中的大鼠对氨基糖苷类毒性高度敏感，早期表现为外毛细胞（OHC）的破坏。在本研究中，畸变产物耳声发射（DPOAE）专门用于测量OHC的微机械活动，被用来评估对三组代表不同出生后发育阶段的新生大鼠给予卡那霉素方案后的功能影响。通过这种方式，对出生后1 - 10天、11 - 20天和21 - 30天的有色大鼠进行了治疗。在治疗后期间获得的一系列2f1 - f2 DPOAE的输入-输出（I/O）函数表明，出生后1 - 10天和11 - 20天接受治疗的动物的检测阈值显著升高，在较高测试频率下观察到最大的升高。
