静脉注射甲氧氯普胺对血压正常和高血压受试者血压的影响。
The effect of intravenous metoclopramide on blood pressure in normotensive and hypertensive subjects.
作者信息
Blanco M, Jelambi I, Pérez G, Gómez J, Franco T, Hurtado N, Velasco M
机构信息
Clinical Pharmacology Unit, Vargas Medical School, Central University of Venezuela, Caracas, SA.
出版信息
Int J Clin Pharmacol Ther. 1996 Sep;34(9):390-2.
In the present study we evaluated the effect of intravenous metoclopramide on blood pressure in normotensive (untrained, football players, runners) and hypertensive subjects. There was a decrease in blood pressure only observed in untrained female subjects and this was greater in hypertensive subjects. In football players and runners the decrease in blood pressure was not statistically significant. There was no significant effect on heart rate. The probable mechanism of this new pharmacological effect of metoclopramide is unknown, however, research is now in progress to define its mechanism of action.
在本研究中，我们评估了静脉注射甲氧氯普胺对血压正常者（未受过训练者、足球运动员、跑步者）和高血压患者血压的影响。仅在未受过训练的女性受试者中观察到血压下降，且在高血压患者中下降幅度更大。在足球运动员和跑步者中，血压下降无统计学意义。对心率无显著影响。甲氧氯普胺这种新药理作用的可能机制尚不清楚，不过，目前正在进行研究以确定其作用机制。
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