Sparks D L, Davis D G, Bigelow T M, Rasheed K, Landers T M, Liu H, Coyne C M, Hunsaker J C
Department of Pathology, University of Kentucky Medical Center, Lexington 40536-0230, USA.
J Child Neurol. 1996 Mar;11(2):101-7. doi: 10.1177/088307389601100208.
Neuronal expression of the ALZ-50 epitope was investigated in hippocampus and medulla from infants dying of sudden infant death syndrome or known causes (controls). Hippocampal studies include data from 31 infants dying of known causes between 32 weeks' gestation and 16 months postpartum and 46 infants who died of sudden infant death syndrome. The medulla at the level of the mid olivary protuberance was investigated in 22 infants with sudden infant death syndrome and 11 controls matched for age and postmortem interval. Medullary sections were also examined using immunohistochemical methods to demonstrate reactivity to glial fibrillary acidic protein antibody. The density of ALZ-50-immunodecorated neurons in control hippocampus rises from the level observable in utero to a maximum between 1 and 4 months of age and declines thereafter. The density of ALZ-50-immunoreactive neurons in hippocampus is significantly increased in infants with sudden infant death syndrome at all ages. Significant regionally specific increases in the number of ALZ-50-immunoreactive neurons, and glial fibrillary acidic protein-reactive cells were found in sudden infant death syndrome medulla; coincidental increases were observed in only the solitary nucleus. Neurons exhibiting the ALZ-50 epitope may reflect apoptotic neuron death of normal development, and increased numbers of immunoreactive neurons may suggest enhanced neurodegeneration in sudden infant death syndrome.
在死于婴儿猝死综合征（SIDS）或已知病因（对照）的婴儿的海马体和延髓中，研究了ALZ - 50表位的神经元表达。海马体研究包括来自31名在妊娠32周和产后16个月之间死于已知病因的婴儿以及46名死于婴儿猝死综合征的婴儿的数据。在22名死于婴儿猝死综合征的婴儿和11名年龄及死后间隔相匹配的对照婴儿中，研究了橄榄体中部隆起水平的延髓。还使用免疫组织化学方法检查延髓切片，以证明对胶质纤维酸性蛋白抗体的反应性。对照海马体中ALZ - 50免疫装饰神经元的密度从子宫内可观察到的水平上升，在1至4个月龄时达到最大值，此后下降。在所有年龄段的婴儿猝死综合征婴儿中，海马体中ALZ - 50免疫反应性神经元的密度显著增加。在婴儿猝死综合征延髓中发现ALZ - 50免疫反应性神经元和胶质纤维酸性蛋白反应性细胞的数量有显著的区域特异性增加；仅在孤束核中观察到同时增加。表现出ALZ - 50表位的神经元可能反映正常发育过程中的凋亡性神经元死亡，免疫反应性神经元数量增加可能表明婴儿猝死综合征中神经退行性变增强。
