氨基酸的α-酮酸类似物对D-氨基酸氧化酶的抑制作用。
Inhibition of D-amino acid oxidase by alpha-keto acids analogs of amino acids.
作者信息
Moreno J A, Montes F J, Catalán J, Galán M A
机构信息
Department of Chemical Engineering, University of Salamanca, Spain.
出版信息
Enzyme Microb Technol. 1996 Apr;18(5):379-82. doi: 10.1016/0141-0229(95)00138-7.
The inhibition of D-amino acid oxidase by certain alpha-keto acids products of the reaction with D-amino acids, in particular alpha-keto acids that are analogs of the amino acids alanine, valine, leucine, phenylanaline, phenylglycine, tyrosine and tryptophan, is reported. All the alpha-keto acids assayed behaved as substrate competitive inhibitors of the enzyme. The relationship between the degree of inhibition and the structure of the inhibitor is discussed.
据报道，某些与D-氨基酸反应的α-酮酸产物，特别是丙氨酸、缬氨酸、亮氨酸、苯丙氨酸、苯甘氨酸、酪氨酸和色氨酸的氨基酸类似物α-酮酸，可抑制D-氨基酸氧化酶。所有检测的α-酮酸均表现为该酶的底物竞争性抑制剂。文中讨论了抑制程度与抑制剂结构之间的关系。
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