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血清CYFRA 21-1与鳞状细胞癌抗原在肺鳞状细胞癌诊断中的比较

A comparison of serum CYFRA 21-1 and SCC Ag in the diagnosis of squamous cell lung carcinoma.

作者信息

Kim Y C, Park K O, Choi I S, Kim H J, Lim S C, Bom H S

机构信息

Department of Internal Medicine and Nuclear Medicine, Chonnam National University, Kwangju, Korea.

出版信息

Korean J Intern Med. 1996 Jan;11(1):50-7. doi: 10.3904/kjim.1996.11.1.50.

DOI:10.3904/kjim.1996.11.1.50
PMID:8882476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4532001/
Abstract

To evaluate the usefulness of CYFRA 21-1 and SCC Ag in the diagnosis of squamous cell carcinoma (SQC) of the lung, we tested sera from 124 patients with lung cancers (squamous cell ca 72, adenoca 22, large cell ca 4, small cell ca 18 and undetermined 8) and 78 patients with inflammatory lung diseases (bronchitis 24, bronchiectasis 29, tuberculosis 19 and others 6) using immunoradiometric assay kit for cytokeratin fragment 19 (CYFRA 21-1) and radioimmunoassay kit for SCC Ag. The serum CYFRA 21-1 and SCC Ag were significantly higher in lung cancer patients compared with control subjects. However, the significant difference was restricted only to SQC. In patients with SQC, CYFRA 21-1 and SCC Ag showed significantly higher levels according to the advanced anatomic stages (stage I-IIIa vs. stage IIIb, IV, p < 0.05). There was a good correlation between CYFRA 21-1 and SCC Ag (r = 0.41, p < 0.001). Receiver operating characteristic (ROC) curves were generated from results of both tumor markers and areas under the curves (AUC) were calculated. AUC of CYFRA 21-1 (0.93) were significantly larger than that of SCC Ag (0.77) for the diagnosis of SQC (p < 0.05). Therefore, we conclude that CYFRA 21-1 is superior to SCC Ag in the diagnosis of squamous cell carcinoma of the lung.

摘要

为评估细胞角蛋白19片段（CYFRA 21-1）和鳞状细胞癌抗原（SCC Ag）在肺癌鳞状细胞癌（SQC）诊断中的应用价值，我们使用细胞角蛋白片段19免疫放射分析试剂盒（CYFRA 21-1）和SCC Ag放射免疫分析试剂盒，检测了124例肺癌患者（鳞状细胞癌72例、腺癌22例、大细胞癌4例、小细胞癌18例及未定型8例）和78例肺部炎症性疾病患者（支气管炎24例、支气管扩张29例、肺结核19例及其他6例）的血清。肺癌患者血清CYFRA 21-1和SCC Ag水平显著高于对照组。然而，显著差异仅局限于SQC。在SQC患者中，根据解剖学分期进展（I-IIIa期与IIIb、IV期相比，p<0.05），CYFRA 21-1和SCC Ag水平显著升高。CYFRA 21-1与SCC Ag之间存在良好的相关性（r = 0.41，p<0.001）。根据两种肿瘤标志物的结果绘制受试者工作特征（ROC）曲线，并计算曲线下面积（AUC）。CYFRA 21-1诊断SQC的AUC（0.93）显著大于SCC Ag的AUC（0.77）（p<0.05）。因此，我们得出结论，CYFRA 21-1在肺癌鳞状细胞癌的诊断中优于SCC Ag。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/735f0c17adcb/kjim-11-1-50-6f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/7fb173c1d07b/kjim-11-1-50-6f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/72fac3f92789/kjim-11-1-50-6f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/3fdd6c79924c/kjim-11-1-50-6f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/735f0c17adcb/kjim-11-1-50-6f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/7fb173c1d07b/kjim-11-1-50-6f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/72fac3f92789/kjim-11-1-50-6f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/3fdd6c79924c/kjim-11-1-50-6f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384b/4532001/735f0c17adcb/kjim-11-1-50-6f4.jpg

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