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琥珀酰亚胺对大鼠高草酸尿症的影响:草酸尿不同给药方法的估计值。

Effect of succinimide on hyperoxaluria in the rat estimated value of the different dosing methods of oxaluria.

作者信息

Thomas J, Duburque M T, Champagnac A, Jean S

出版信息

Urol Int. 1977;32(1):1-7. doi: 10.1159/000280105.

DOI:10.1159/000280105
PMID:888249
Abstract

In the female rat intoxicated with ethylene glycol the oxaluria increases with the degree of intoxication. The increase is less in the animals treated with succinimide. The comparative study of the results of the dosages made with gas-liquid-chromatography and by various colorimetric methods show that this later gives varying results and underestimates high concentrations of oxalic acid. The result is that any study based on results of dosages of urinary oxalic acid made by colorimetry must be taken with some reserve, and this on whether the oxalic lithiasis is experimentally induced or human, or whether its evolution is spontaneous or influenced by a therapeutic.

摘要

在用乙二醇中毒的雌性大鼠中,草酸盐尿症随中毒程度增加。在用琥珀酰亚胺治疗的动物中增加较少。用气相色谱法和各种比色法进行剂量测定结果的比较研究表明,后者给出的结果各不相同,并且低估了高浓度的草酸。结果是,任何基于比色法测定尿草酸结果的研究都必须有所保留,无论草酸结石是实验诱导的还是人类的,或者其演变是自发的还是受治疗影响的。

相似文献

1
Effect of succinimide on hyperoxaluria in the rat estimated value of the different dosing methods of oxaluria.琥珀酰亚胺对大鼠高草酸尿症的影响:草酸尿不同给药方法的估计值。
Urol Int. 1977;32(1):1-7. doi: 10.1159/000280105.
2
[The role of oxaluria in the pathogenesis of oxalic lithiasis].[草酸尿在草酸结石发病机制中的作用]
J Int Coll Surg. 1962 Sep;38:252-7.
3
[Study of 24-hour oxaluria in oxalic lithiasis].[草酸钙结石患者24小时尿草酸研究]
Rein Foie. 1962 Jun;4:II/179-88.
4
[Oxaluria in urinary lithiasis].[尿路结石中的草酸尿症]
Presse Med. 1983 Sep 17;12(32):1991-4.
5
[Monohydrate and dihydrate oxalic lithiasis. Calculi, their macroscopic structure (radiographic and therapeutic impact). Calciuria and oxaluria].[一水合草酸钙结石和二水合草酸钙结石。结石及其宏观结构(影像学和治疗影响)。高钙尿症和高草酸尿症]
Nephrologie. 1984;5(4):181-3.
6
[Therapeutic effect of pyridoxine and succinimide in the treatment of a patient with primary hyperoxaluria].
Arch Esp Urol. 1986 May;39(4):279-82.
7
[Experimental oxalic lithiasis induced with glyoxylic acid in rats. Attempted prevention with succinimide].[大鼠乙醛酸诱导实验性草酸结石。用琥珀酰亚胺尝试预防]
Therapie. 1971 Sep-Oct;26(5):991-8.
8
[Influence of succinimide on experimental rat urinary calculi].
C R Seances Soc Biol Fil. 1976;170(4):750-3.
9
"Bicarbonate resistant" metabolic acidosis in association with ethylene glycol intoxication.与乙二醇中毒相关的“碳酸氢盐抵抗性”代谢性酸中毒。
Clin Toxicol. 1976;9(1):53-60. doi: 10.3109/15563657608995406.
10
Urine and tissue oxalate and hippurate levels in ethylene glycol intoxication in the dog.
Vet Hum Toxicol. 1982 Oct;24(5):331-4.

引用本文的文献

1
Preventive effect of some substances on experimental oxalic calculogenesis in the frog.
Urol Res. 1981;9(2):63-6. doi: 10.1007/BF00256678.