Haase K K, Karsch K R
Medizinische Klinik, Abteilung III Eberhard-Karls-Universität Tübingen.
Z Kardiol. 1996;85 Suppl 1:81-6.
From 1988 to 1995, approximately 10,000 patients with coronary artery disease have been treated using excimer laser angioplasty. All data underline the feasibility and safety of this technique. However, coronary excimer laser angioplasty has been performed as a stand-alone procedure in a minority of patients, only, either due to an insufficient angiographic result, or due to complications such as abrupt vessel closure, severe dissection or perforation. Clinical and angiographic follow-up studies have also documented that excimer laser angioplasty does not reduce the incidence of restenosis following the coronary intervention. Experimental results underline the importance of pressure waves and bubble formations, which can cause additional vessel wall trauma despite thermal injury. Promising new laser devices should offer high ablation rates with only minimal thermal and acoustic tissue injury. It is expected that such laser devices will emit in the mid-infrared spectrum of light.
从1988年到1995年，大约10000例冠心病患者接受了准分子激光血管成形术治疗。所有数据都表明了该技术的可行性和安全性。然而，仅在少数患者中，准分子激光血管成形术是作为一种独立的手术进行的，这要么是因为血管造影结果不理想，要么是由于诸如血管突然闭塞、严重夹层或穿孔等并发症。临床和血管造影随访研究也证明，准分子激光血管成形术并不能降低冠状动脉介入治疗后再狭窄的发生率。实验结果强调了压力波和气泡形成的重要性，尽管存在热损伤，但它们仍会导致额外的血管壁创伤。有前景的新型激光设备应能提供高消融率，同时仅造成最小程度的热和声学组织损伤。预计此类激光设备将在中红外光谱范围内发射。
