Riessen R, Oberhoff M, Karsch K R
Med. Klinik III, Universität Tübingen.
Z Kardiol. 1996;85 Suppl 1:87-98.
Local drug delivery is a new therapeutic approach targeted at the prevention of restenosis after coronary balloon angioplasty. Several mostly catheter-based devices have been designed to deliver medications with, for example, antithrombotic or antiproliferative actions directly at the site of angioplasty. Besides delivery of conventional pharmacologic agents, novel therapeutic strategies based on molecular mechanisms (e.g., gene transfer or antisense oligonucleotides) are currently under investigation and at the threshold of clinical trials. In addition, local radiation with either radioactive wires or stents has shown promising results in first experimental studies. More investigations are necessary, however, to clearly demonstrate the efficacy of the various local delivery approaches, with a special emphasis on safety aspects.
局部药物递送是一种旨在预防冠状动脉球囊血管成形术后再狭窄的新型治疗方法。已经设计了几种主要基于导管的装置，用于在血管成形术部位直接递送具有抗血栓或抗增殖作用等的药物。除了递送传统的药理剂外，基于分子机制的新型治疗策略（例如基因转移或反义寡核苷酸）目前正在研究中，并且即将进入临床试验阶段。此外，使用放射性导线或支架进行局部放射在最初的实验研究中已显示出有希望的结果。然而，需要更多的研究来清楚地证明各种局部递送方法的疗效，尤其要强调安全性方面。
