人生长激素（6 - 13）降血糖类似物的结构与体内活性
Structure and in vivo activity of hypoglycaemic analogues of human growth hormone (6-13).
作者信息
Thompson P, Lim N, Ede N J, Ng F M, Rae I D, Hearn M T
机构信息
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
出版信息
Drug Des Discov. 1995 Aug;13(1):55-72.
PMID:8882901
Abstract
A range of peptide analogues related to Asu11-human growth hormone (6-13) have been synthesized and tested for hypoglycaemic activity using in vivo insulin tolerance tests. Utilising an alanine scan procedure and a selective amino acid residue approach these structure-activity studies suggest that residues Phe10, Arg8 and the C-terminal beta-turn structure are important for the expression of biological activity.
摘要
已经合成了一系列与天冬酰胺-11-人生长激素（6-13）相关的肽类似物，并使用体内胰岛素耐量试验测试了它们的降血糖活性。利用丙氨酸扫描程序和选择性氨基酸残基方法，这些构效关系研究表明，苯丙氨酸10、精氨酸8残基和C末端β-转角结构对于生物活性的表达很重要。
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