异环磷酰胺两种剂量水平用于恶性间皮瘤治疗

Two dose levels of ifosfamide in malignant mesothelioma.

作者信息

Içli F, Karaoğuz H, Hastürk S, Kurt B, Akbulut H, Dinçol D, Demirkazik A, Cay F, Akyar S

机构信息

Ankara University Medical School, Ibn-i Sing Hospital, Medical Oncology Department, Ankara, Turkey.

出版信息

Lung Cancer. 1996 Sep;15(2):207-13. doi: 10.1016/0169-5002(96)00584-3.

DOI:10.1016/0169-5002(96)00584-3

PMID:8882987

Abstract

Thirty-one consecutive patients with histologically proven and symptomatic malignant mesothelioma were treated with two dose levels of ifosfamide. The first group of 15 patients were given 2.3 g/m2/day for 5 days (group A) and the following 16 patients were treated with 1.2 g/m2/day for 5 days of ifosfamide (group B). Treatment cycles were repeated every 3 weeks. While the partial response rate (PR) in group A was 38.5%, it was only 6.25% in group B (P > 0.05). The 95% confidence interval for the difference in PR rates was 3.3-61.2% > The overall survival (OAS) of groups A and B were similar (8 months and 9 months, respectively). Higher Grade 3-4 myelotoxicity was observed in group A when compared to group B (30.8% vs. 18.7%; P > 0.05). In conclusion, a favourable response rate could be achieved in malignant mesothelioma with high dose ifosfamide at the cost of increased toxicity.

摘要

31例经组织学证实且有症状的恶性间皮瘤患者接受了两种剂量水平的异环磷酰胺治疗。第一组15例患者接受2.3 g/m²/天，共5天的治疗（A组），随后的16例患者接受1.2 g/m²/天，共5天的异环磷酰胺治疗（B组）。治疗周期每3周重复一次。A组的部分缓解率（PR）为38.5%，而B组仅为6.25%（P>0.05）。PR率差异的95%置信区间为3.3 - 61.2%。A组和B组的总生存期（OS）相似（分别为8个月和9个月）。与B组相比，A组观察到更高的3 - 4级骨髓毒性（30.8%对18.7%；P>0.05）。总之，高剂量异环磷酰胺治疗恶性间皮瘤可取得较好的缓解率，但代价是毒性增加。