Runnebaum I B, Köhler T, Stickeler E, Kieback H R, Kreienberg R
Department of Obstetrics and Gynaecology, University of Ulm, Germany.
Br J Cancer. 1996 Oct;74(8):1157-60. doi: 10.1038/bjc.1996.510.
Fallopian tube carcinoma (FTC) is a rare but lethal gynaecological malignancy. Four out of seven FTCs were identified with three point missense mutations, one single base deletion and one silent point mutation in the p53 gene. Genital-type HPV sequences were not detected. The S-phase fraction of tumours with mutant and wild-type p53 was 25.74% (median) and 12.55% (median) respectively.
输卵管癌（FTC）是一种罕见但致命的妇科恶性肿瘤。在七个FTC病例中，有四个被发现p53基因存在三个点错义突变、一个单碱基缺失和一个沉默点突变。未检测到生殖器型人乳头瘤病毒（HPV）序列。p53基因发生突变和野生型的肿瘤的S期分数分别为25.74%（中位数）和12.55%（中位数）。
